Six years after KiDULTHOOD, Sam Peel is released from jail for killing Trife, he realizes that life is no easier on the outside than it was on the inside and he's forced to confront the people he hurt the most. Some have moved on, others are stuck with the repercussions of his actions that night, but one thing's for certain - everyone has been forced to grow up. Through his journey Sam struggles to deal with his sorrow and guilt and something else he didn't expect - those seeking revenge. As he's pursued by a new generation of bad boys, Sam sets about trying to get the message across to his pursuers that they should stop the violence, much like Trife tried to tell him all those years ago. Can Sam stop the cycle of violence and make something positive from the destruction he caused or will his journey into Adulthood end here?

First, there was Kidulthood, then Adulthood, and now comes Noel Clarke's last instalment: Brotherhood. With Sam facing up to the new world, he realizes it also comes with new problems and new challenges that he must face that he knows, will require old friends to help him survive new dangers.

Set in the future, the film is about the development of new cutting-edge bioweapon. Traumatized ex-soldier Ryan Reeve wakes up in the back of a moving van next to a young boy who has been kidnapped, he attempts to free the boy, but blacks out. He is forced to work out what is happening in bursts of time no longer than ten minutes, before his mind is taken over again. He teams up with the mysterious "Dana" as he battles a conspiracy known as "Anomaly" led by Harkin Langham, and learns that the bioweapon is the same mind control that has allowed its creator to take over his body.